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Curriculum vitae — education, research experience, publications, and awards.
Basics
| Name | Xiangjian Zeng |
| Label | Ph.D. Student, Electrical Engineering and Computer Science |
| azeng@mit.edu | |
| Phone | (412) 579-1999 |
| Url | https://aaronzeng-cmu.github.io/ |
| Summary | To research brain physiology with computational modeling and create a functional neuromodulation system with engineering toolsets. |
Work
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2024.09 - Present Research Assistant
Lewis Lab, Massachusetts Institute of Technology
Closed-loop Auditory Modulation of Cerebrospinal Fluid during Sleep
- Develop a closed-loop neuromodulation system that performs real-time scalp-EEG filtering and machine-learning-based slow-oscillation phase prediction to deliver precisely timed auditory stimulation during sleep
- Integrate simultaneous EEG-fMRI with electrophysiological and CSF-flow analyses to quantify stimulation-evoked brain and fluid dynamics across younger and older adults
- Co-authored a Science Translational Medicine study showing that closed-loop auditory stimulation targeting sleep slow waves modulates cerebrospinal fluid flow in humans
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2023.05 - 2024.08 Research Assistant
Insanally Lab, University of Pittsburgh
Bayesian ensemble neural decoding and spiking recurrent neural network simulation
- Developed a probabilistic ensemble neural decoder, combining inter-spike-interval-based conditional probabilities across multiple neurons to jointly predict behavioral trial conditions, revealing that traditionally neglected quiet non-classically responsive neurons interact with responsive neurons in learning
- Demonstrated that aggregating non-classically responsive population activity improved behavioral decoding accuracy from 60% to 65% during late-stage learning compared with early learning
- Built spiking recurrent neural-network models with 1000 units in Python and Julia under biological constraints to simulate cortical mechanisms underlying auditory discrimination behavior
- Investigated how flexible neural-network dynamics emerge from balanced excitatory and inhibitory activity and authored a manuscript describing the resulting computational model
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2022.05 - 2023.04 Research Assistant
Chamanzar Lab, Carnegie Mellon University
Neural Probe Waveguide Characterization System
- Developed an automated, non-destructive characterization system for photonic waveguides used in neural optical probes by integrating robotics, computer vision, and signal processing
- Demonstrated waveguide-loss characterization previously achievable primarily through destructive methods and first-authored a peer-reviewed conference proceedings paper describing the pipeline
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2020.03 - 2021.01 Research Assistant
Lerman Lab, UC San Diego
Adaptive neural signal processing and peripheral nerve magnetoneurography
- Led development of an adaptive filtering algorithm for suppressing power-line interference in peripheral nerve recordings and implemented the method in a hardware demonstration
- Achieved approximately 45 dB suppression of 60 Hz interference and presented the work as first author at the North American Neuromodulation Society meeting
- Developed MATLAB signal-cleaning and processing pipelines for magnetic measurements of peripheral nerve activity, contributing analyses to a collaborative publication
- Supported human neuroscience studies involving peripheral nerve measurements and electrical stimulation
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2019.10 - 2020.12 Research Assistant
Spitzer Lab, UC San Diego
Automated Fluorescence Cell Counting
- Developed an automatic cell recognition program for fluorescence brain slices in Matlab utilizing correlation to count and map a variety of brain cells, obtaining an accuracy close to expert manual selection
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2019.07 - 2019.08 Research Assistant
Neuroelectronics Group, La Jolla, San Diego
Neural Recording Amplifier PCB Design
- Designed, assembled, and tested an Altium PCB for an amplifier used in in vivo neural recording
- Reduced the redesigned amplifier-board footprint to approximately 3 cm x 1 cm, more than twofold smaller than the previous design
Volunteer
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2025.11 - 2025.11 San Diego, CA
Conference Presenter (First Author)
Society for Neuroscience
Auditory Stimulation During Sleep Modulates CSF Flow via Dual Slow-Wave and High Frequency Pathways
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2024.10 - 2024.10 Chicago, IL
Conference Presenter (First Author)
Society for Neuroscience
Contributions and synaptic basis of diverse cortical neuron response to flexible task performance
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2024.03 - 2024.03 Montreal, Canada
Conference Presenter (First Author)
COSYNE
Contributions and synaptic basis of diverse cortical neuron response to flexible task performance
Education
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2024.09 - 2029.06 Cambridge, MA
PhD
Massachusetts Institute of Technology
Electrical Engineering and Computer Science
- Functional Magnetic Resonance Imaging: Data Acquisition and Analysis
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2021.09 - 2023.12 Pittsburgh, PA
Master
Carnegie Mellon University
Electrical and Computer Engineering
- Intro to Deep Learning
- Machine Learning for Signal Processing
- Neuroengineering Laboratory
- Advanced System Neuroscience
- Micro and Nano Systems Fabrication
- Nano-Bio-Photonics
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2016.09 - 2020.12 La Jolla, CA
Bachelor
University of California San Diego
Electrical and Computer Engineering (Minor in Cognitive Science)
- Cognitive Neuroscience
- Linear Electronic Systems
- Introduction to Digital Design
- Components and Circuits Laboratory
Awards
- 2026.01.01
EECS MathWorks Fellowship
Massachusetts Institute of Technology
Electrical Engineering and Computer Science
- 2025.01.01
MIT Artificial Intelligence and Wellness Fellowship
Massachusetts Institute of Technology
- 2020.12.01
Magna Cum Laude
University of California San Diego
Bachelor's degree in Electrical and Computer Engineering
Certificates
| Functional Magnetic Resonance Imaging: Data Acquisition and Analysis | ||
| Massachusetts Institute of Technology | 2024-01-01 |
| Advanced System Neuroscience | ||
| Carnegie Mellon University | 2022-01-01 |
| Neuroengineering Laboratory | ||
| Carnegie Mellon University | 2022-01-01 |
| Machine Learning for Signal Processing | ||
| Carnegie Mellon University | 2022-01-01 |
| Intro to Deep Learning | ||
| Carnegie Mellon University | 2022-01-01 |
| Cognitive Neuroscience | ||
| University of California San Diego | 2020-01-01 |
Publications
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2026.09.09 Closed-loop auditory stimulation in phase with slow waves during sleep enhances cerebrospinal fluid flow in humans
Science Translational Medicine
Co-author. Closed-loop auditory stimulation aligned with sleep slow waves enhances cerebrospinal fluid flow in humans.
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2025.11.15 Auditory Stimulation During Sleep Modulates CSF Flow via Dual Slow-Wave and High Frequency Pathways
Society for Neuroscience, San Diego, USA
First author conference presentation
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2024.10.05 Contributions and synaptic basis of diverse cortical neuron response to flexible task performance
Society for Neuroscience / COSYNE
First author conference presentations
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2024.01.01 Dynamic gating of perceptual flexibility by non-classically responsive neurons
Manuscript in review
Co-authored paper on Bayesian ensemble neural decoding
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2023.01.01 Automated Photonic Waveguide Loss Measurement using Out-scattering Light Method
Integrated Systems Design and Technology Conference 2023
First author paper publication
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2021.01.15 Capturing the Magnetic Signature of Small Fiber Neuronal Activity
North American Neuromodulation Society Virtual Meeting
Co-authored conference publication
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2021.01.15 RLS Harmonic Powerline Noise Cancellation in Radial Nerve Recording
North American Neuromodulation Society Virtual Meeting
First author conference publication
Skills
| Programming and Machine Learning | |
| Python | |
| C/C++ | |
| MATLAB | |
| Julia | |
| R | |
| PyTorch | |
| TensorFlow | |
| scikit-learn |
| Neural Data and Modeling | |
| EEG | |
| EEG-fMRI | |
| Electrophysiology | |
| Neural decoding | |
| Adaptive filtering | |
| Computational modeling |
| Neurotechnology | |
| Closed-loop stimulation | |
| Peripheral nerve recording | |
| Real-time signal processing |
| Hardware and Prototyping | |
| PCB design | |
| Altium | |
| Microfabrication | |
| Simulink | |
| SolidWorks |
Languages
| English | |
| Fluent |
| Chinese | |
| Native speaker |
Interests
| Brain Physiology and Neuromodulation | |
| Computational modeling | |
| Functional neuromodulation | |
| Sleep research | |
| Cerebrospinal fluid dynamics |
References
| Professor Laura D. Lewis | |
| Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Email: ldlewis@mit.edu |
| Professor Michele Insanally | |
| Otolaryngology & Neurobiology, University of Pittsburgh. Phone: 412-648-4620, Email: mni@pitt.edu |
| Professor Badr F. Albanna | |
| Neuroscience, University of Pittsburgh School of Medicine. Email: badr.albanna@gmail.com |
Projects
- 2024.09 - Present
Closed-loop Auditory Modulation of Cerebrospinal Fluid during Sleep
Real-time EEG phase prediction for closed-loop auditory stimulation of cerebrospinal fluid flow during sleep
- 2022.09 - 2022.12
Deep Learning Automatic Fake News Detection
BERT-based language model to extract relevant evidence and classify misinformation from political statements, achieving 72% two-way accuracy
- 2022.09 - 2022.12
EEG-based Music Recommendation
KNN system to detect musical preferences from EEG and update recommendations in real-time
- 2023.05 - 2024.08
Bayesian Ensemble Neural Decoding
Ensemble decoder incorporating multiple neurons to predict mouse auditory discrimination behavior
- 2022.05 - 2023.04
Neural Probe Waveguide Characterization System
Light-scattering characterization with robotics, computer vision, and signal processing